Dr. Meredith Grey: [after a one-night stand with Derek Shepherd] Look, I'm gonna go upstairs and take a shower, OK? And when I get back down here, you won't be here.

Dr. Isobel "Izzie" Stevens: You kissed me.
Dr. Alex Karev: Yes, I did.
Dr. Isobel "Izzie" Stevens: Should we?... I mean, there's a discussion that we could have... if you wanted to have one?
Dr. Alex Karev: Izzie, I kissed you, with tongue, and I plan to do it again and again - get used to it. End of
discussion.
Dr. Isobel "Izzie" Stevens: Ok.

Denny Duquette: I've been lying in this bed for close to a year, and I've had a lot of time to look back on my life. And the things that I remember best - those are the things I wasn't supposed to do and I did them anyway. The thing is, life is too damn short to be following these rules.

Dr. Alex Karev: So, Grey and Stevens really walk around in their underwear?
Dr. George O'Malley: Um... Not all the time. I mean, some of the time. But not all the time.
Dr. Alex Karev: Sexy underwear?
Dr. George O'Malley: Yeah...
Dr. Alex Karev: And they just let you look at them?
Dr. George O'Malley: Well, uh... yeah.
Dr. Alex Karev: Like sisters?
Dr. George O'Malley: No! Not like sisters. Uh... no! I don't think of them like sisters.
Dr. Alex Karev: But they're no coming on to you?
Dr. George O'Malley: Not exactly.
Dr. Alex Karev:
They don't expect you to do anything.
Dr. George O'Malley: No, but...
Dr. Alex Karev: Like sisters. Just like sisters.

Dr. George O'Malley: 007. They're calling me 007, aren't they?
Izzie & Meredith: No-one's calling you 007.
Dr. George O'Malley: I was on the elevator and Murphy whispered 007.
Dr. Cristina Yang: Okay, how many times are we going to go through this, George? Five, ten? Give me a number or else I'm gonna hit you.
Dr. George O'Malley: Murphy whispered 007 and everyone laughed.
Dr. Isobel "Izzie" Stevens: He wasn't talking about you.
Dr. George O'Malley: Are you sure?
Dr. Meredith Grey: Would we lie to you?
Dr. George O'Malley: Yes!

Dr. Miranda Bailey: Every intern wants to perform their first surgery. That's not your job. Do you know what your job is? To make your resident happy. Do I look happy? No! Why? Because my interns are whiney. You know what will make me look happy? Having the code team staffed, having the trauma pages answered, having the weekend labs delivered and having someone down in the pit
doing the sutures. No-one holds a scalpel until I'm so happy I'm Mary Freaking Poppins.

Dr. Cristina Yang: [about inviting Burke to Thanksgiving dinner] What was I supposed to do? Blow off my boyfriend for Thanksgiving?
[pause]
Dr. Cristina Yang: I tried to. He wouldn't blow. He's like something sticky that won't blow off.